In this paper, rubber test data were fitted with hyperelastic models in ABAQUS finite-strain package. On the basis of the fitting results, a proper model was chosen. Furthermore, dynamic response of chiral honeycomb rubber claddings subjected to UNDEX has been investigated, and the influence of main design parameters including height, porosity and panel material on shock resistance was discussed. It is found that as cladding’s height, porosity and panel wave impedance increase, its shock resistance and buffering effect will be improved. The results show not only play an instructive role in understanding the protective mechanism and performance of chiral honeycomb claddings subjected to underwater explosion, but also provide a guideline to further optimal design.