The layout of pipes has an effect on flowing characteristics of fluid and their stress distribution.Fluid-solid interaction characteristics of fluid in pipes with different curvatures were analyzed with the finite element method.The effects of fluid-solid interaction on the equivalent stress of pipes with different curvatures and positions were studied.The results were shown that fluid acts an additional force on the internal surface of bent pipes to cause pipes’ deformation and bending angle changes cause stress fluctuation at both pipes’ inlet and outlet; moreover,the changes of pipe curvatures have a larger effect on bent pipes’ stress near the bending position; the pipe bending stress decreases at first,then increases and decreases again with increase in bending angle of pipes whereas the changing levels of stresses on inner side and both sides are different; the change of pipe curvature radius affects the stress distribution of pipes; the layout of pipes according to R30(R/d=1.5) is more reasonable than others.