Wind loading is the control load for the design of cooling tower. The real mean wind pressure coefficient distribution curve which varying with tower height is simplified as a height-constant curve in design code, and this simplification may has an adverse effect on the design of a 200m high super large cooling tower of an nuclear power plant. Wind tunnel test were carried out to measure real mean wind pressure coefficient distribution curve , and then analysis on three-dimensional effect of wind load on the outer surface of the cooling tower was done, finally the wind-induced responses under the action of real curve and simplified curve were compared by finite element method. The test result indicated that wind loading of both two ends significantly greater than the middle. It was also shown that the wind-induced responses under the action of real curve and simplified curve are basically consistent due to wind load distribution is more important than magnitude for cooling tower wind-induced response, and the simplified curve could be used to design the super large cooling tower.