By means of an explicit nonlinear dynamic finite element computer code LS-DYNA，regarding 75g column and 200g bulk TNT as explosion resource respectively，the nonlinear dynamic response process of the cylindrical shell subjected to explosion laterally were numerically simulated with Euler-Lagrange coupling method，the dynamic responses of setting different ways of explosion source were described. Numerical simulation results show that failure characteristics of shell wall were close connection with charge Q and setting ways of explosion source，setting vertical way of explosion with 75g column TNT source had fierce failure effect and setting parallel way of explosion with central line of 200g bulk TNT long side had the same result. The results provide important reference for the blast-resistant properties analysis and safety assessment of oil-gas pipes safety.