SRC frame-bent hybrid structure is a new type of main building system for thermal power plants, and reasonable arrangement of shear walls can make the structure have three anti-seismic lines. ABAQUS finite element software is used to analyze the elastic-plastic seismic response of the structure under 8 degree minor earthquake, 8 moderate earthquake, 8 major earthquake and 9 degree major earthquake, to acquire the base shear, lateral displacement, inter-story drift and damage evolutionary character of the structure under different earthquake intensities. The results show that: the shear wall is damaged firstly under strong earthquake, which can be the first anti-seismic line, and this can enhance the earthquake resistance of the structure effectively; as the earthquake intensity increase, the weak part of the structure is down from coal hopper floor to operation floor and to bottom two stories, and the lateral displacement curve is shifting from shear-moment-type toward shear-type; the deformation performance of the whole structure is well, which can make the structure meet the requirement of “no collapse under severe earthquake”. Finally, the reasonable arrangement and seismic tectonic measure of shear wall under different earthquake intensities and different site category are advised through calculation analysis, which could be referred by engineering design.