As the number of elevated bridge of high-speed railway grows, the possibility of the bad effect on the running safety of trains caused by the collision between motors and bridge piers also increases. A model test based on the equipment of vehicle-track-bridge coupling system is carried to analyze the variation of bridge and vehicle’s running safety under lateral collision force. The collision force's time history, dynamic strain on the bottom of pier, dynamic displacement and acceleration time history on the top of pier, the dynamic displacement at 1/4, 1/2 and 3/4 span of the bridge beam, and the tri-direction acceleration time histories of the vehicle are obtained. The vibration characteristics such as pier natural frequencies are also calculated. The results show that the lateral collision greatly increases the dynamic responses of the bridge, which may dramatically affect the running safety of vehicles. According to the collision time history, the methods of calculating equivalent static forces are discussed and verified in this field, which may provide a reference for engineering design.