Abstract：According to analyzing the vibration characteristic of high-speed locomotive and the Bouc-Wen model of magnetorheological damper, a vibration control method based on magnetorheological damper was put forward, and a seventeen-degree-of-freedom lateral semi-active control model of high-speed locomotive with magnetorheological damper was established. Taking into account of the nonlinear of model, a fuzzy control rule and a self-adapt control strategy to modify the input parameter of magnetorheological damper in time according to control effect was put forward. The simulation of model was studied by using MatLab. The simulation results showed that compared with the passive control and simply fuzzy control, the self-adapt fuzzy semi-active control strategy with magnetorheological damper could attenuate the vibration of the locomotive effectively and improve the ride comfort and stationarity obviously, especially in the domain of 5~8HZ which are sensitive to the human body.