Abstract: The wind pressure on the structural surface and the coupling wind-induced vibration effects of spatial flexible structure were studied. The fluid governing equations and the turbulent model of large eddy simulation (LES) were introduced and iteration solving process for the wind-structure coupling dynamic equations was established. Some accepts describing structural working states such as pre-stress loading state, stable state and coupling state were defined, while the uniform expression for both structural static state and dynamic state were developed. The time-history structural dynamic analysis technique, the unilateral coupling process and the coupling interaction process were applied to a series of computation and comparison on the wind effects of a typical spatial cable-membrane structure. The investigation shows that the structural mean displacements by time-history structural dynamic analysis technique basically accord with those by the unilateral coupling process; however, the greater structural wind-induced vibration coefficient was gotten by the former technique. Moreover, by the coupling interaction process, the structural mean displacements were less than those by the other two, while the greatest structural wind-induced vibration coefficients were gotten.