The effects of seven different roof opening configurations on the net mean wind loads in a closing-ground building were examined using wind tunnel tests. The lift coefficients of roof, shape coefficients of center-line taps on roof and wall, local shape coefficients were specially studied and compared with the values from Code. It is shown that the net mean suctions on the roof are reduced for the configuration of roof center opening, the biggest value of positive shape coefficient on the center-line is +0.32, which should be taken account into the design of structure efficiently. The positive wind pressures in the configuration of roof corner opening are larger than that of roof center opening configuration, which are unfavorable for structure. The Chinese Code was found to significantly underestimate the local wind pressures of corner area Ra for roof center opening configuration, and the local wind pressures for roof corner opening configuration are larger than that of roof center opening configuration, which may be the result of continuing destroyed for the building. The positive wind loads on the windward wall are increased for roof center opening configuration, up to 86%, and the suctions on the backward and leeward wall are reduced largely.