It is that the modal analysis and random vibration analysis are conducted for the product by using the finite element analysis software ANSYS for the analysis of the fatigue of the airborne product structure. Compared with the modal analyzing results, the finite element model is corrected. The stress response power spectral density is obtained from random vibration analyzing. The fatigue damage of the structure is calculated by the frequency domain method. And the simulation results are in agreement with the reliability enhancement testing results. An optimization scheme for the product structure design is given.