Abstract: the flexible pile isolation to active control system is proposed , the system of dynamic analysis model is established, and its vibration and control equations are derived. In a typical flexible pile base-isolated structure, for example, to study the isolation performance and control effect and the main parameters of control effect. Research results show that: the flexible pile isolation system can effectively reduce dissipation structure of the earthquake response, Flexible pile of base-isolation system with active control can effectively reduce the pile cap with the possibility of collision between the casing wall, at the same time, the vertical load the of structure, the upper structure stiffness and the length of the pile have significant influence on the control effect of the structure.