The paper is aimed at studying vibro-acoustic responses of a coupled pump-jet-shafting-suboff system under unsteady hydrodynamic excitations from the pump-jet running in the wake of the suboff model.The excitations of the pump-jet in the rear of the a suboff model were analysed by the computational fluid dynamics (CFD) with a shear stress transfer(SST) k-ω model and the vibro-acoustic responses were predicted by the coupled finite element method(FEM).A mapping method based on radial basis function was established between CFD/structural meshes to obtain the distributed pulsation force on the structural wet surface.The radiated sound was studied by the boundary element method(BEM).Modal shapes, transmitted forces, sound radiation power and radiation directivity pattern were reported to illustrate the characteristics of vibro-acoustic responses.It is shown that the contribution of the rotor is dominant; among three directions components, the longitudinal distributed forces contribute most to responses over the second harmonics of shaft frequency; the responses exhibit peaks at multiple blade passing frequencies and characteristic structural modes, which include the longitudinal mode of hull, the in-phase mode(breathing mode) of propeller as well as the longitudinal mode of propeller-shaft; the vibro-acoustic responses under the distributed pressure on the stator and duct will produce peaks at blade passing frequency(BPF) and 2BPF, which are of the same level as those produced by the distributed pressure on the rotor, however, the magnitude of the vibro-acoustic response will not increase if they are applied simultaneously due to the phase difference and cancellation between them.The conclusions will shed some light on the design and controlling of vibro-acoustic responses of the coupled pump-jet-shafting-suboff-system.