Abstract: The time domain nonlinear dynamic analysis of a steel catenary riser (SCR) is proposed for fatigue life prediction. As the offshore industry moves towards deeper water, steel catenary riser (SCR) has been a successful riser solution for many oil fields in the last decade. However, fatigue is a critical issue for the SCR design. Since the behavior of the SCR is nonlinear in nature, the time domain analysis is better suited to capture the possible nonlinear effects associated with hydrodynamic nonlinearities and structural nonlinear properties than frequency domain. In this work, the simulation of SCR dynamic response due to ocean environmental loads was carried out. The time histories of stress are employed to predict the global riser fatigue life by S-N curves. Results are presented from a parametric study of the SCR to various input parameters like the drag coefficient, buoyancy factors, and seabed stiffness etc. It is shown that the predicted fatigue life is strong dependent on these parameters. The analysis conclusions can help designers to understand the dynamic behavior of the SCR and provide guidance for the selection of some critical parameters that are used in the SCR fatigue design.