In order to predict the fatigue life of rubber isolator, the prediction model is proposed on the basis of experimental data by using the dumbbell-shaped rubber sample, thereby coming up with a corresponding prediction scheme. The fatigue tension experiment of the dumbbell-shaped rubber sample is devised, and then the experimental data is observed. Additionally, the prediction model in the form of power function is fitted by the least square method. Thereafter, three common evaluation parameters, i.e. Logarithmic principal strain, Cauchy principal stress and strain energy density, for fatigue life are computed by the finite element method. Lastly, a comparison is made between the prediction and experimental data. It is concluded that all three parameters can be effectively fitted by that prediction model in the same power function form when the fatigue failure criterion declined to the 25 percent of stiffness. Specifically, the prediction value of logarithmic principal strain closes to the observation; likewise, the prediction magnitude of principal strain density is approximately double of the observation; and the reliability coefficient of fatigue life for Cauchy principal stress is approaching to 5. In addition, the shape of all three fitting curves is similar.