Based on the theories and methods of underground anti-explosion, a simplified calculation method for the dynamic response of segment lining subjected to blast loading was proposed. The lining was composed of a number of rigid arch segments, ignoring the deformation of segments. The dynamic interaction between the segments and the bolts, and the interaction between tunnel lining segment and soil-structure can be properly simulated with the method. As an example, the calculation of the shield section of Nanjing tunnel subjected to blast loading was discussed. The time-history curves of displacement and speed of some key points of section lining were obtained. Furthermore, the influences of the parameters of the segments on dynamic response of tunnel lining were investigated. The result indicates that the simplified method of blasting response analysis can reflect the response of structure subjected to blast loading accurately. It is a simple, convenient and practical calculation method. The results will be a reference for antiknock design of tunnel lining.