Selecting the old barracks and the fort relics, which are situated at Humen, Dongguan, as the research object, the whole 3D model was established for numerical simulation. In order to calculate the structural vibration response caused by the different vehicle speed, the axle weight, the time-historical analysis was completed by using finite element method. The vibration acceleration and velocity was investigated and the effect of moving vehicle load on the relics was analyzed. The results show that if the vehicle speed increases from 40km/h to 80 km/h, the velocity response of the fort base has increased by 4%-13%; also that of the foundation of barracks has increased by 6%-30%. Similarly, if the axle load increases from 15t to 55t, the response of the relics base appears positive correlation with the increasing of the axle weight. By changing the frequency of the vertical harmonic force, the harmonic response analysis was finished. It was shown that the predominant frequencies of the model were close to 10Hz and 40Hz. When the loading frequency was about 10Hz, vibration response of the foundation of the old barracks and the fort reached the maximum value.