Under Bi-directional horizontal seismic load, coupling seismic response of structure would seriously weaken the cylinder deformation capacity and ductility of structure damage, intensified the structure damage. This paper introduces seismic incidence angle to simulate the more objective, effective horizontal seismic excitation that structure may encounter, based on the traditional IDA method, using the Latin hypercube sampling method to consider the common influence of seismic intensity and seismic incidence angle on the structure, the Multi-component Incremental Dynamic Analysis (MIDA)method was introduced. Based on the MIDA method, dynamic time history analysis was carried out on the reinforced concrete core walls according the finite element analysis software Perform-3D, the MIDA curves were obtained to reflect the structural seismic performance. The four limit state points of structure were defined according to the MIDA curves based on the performance, Corresponding seismic fragility curves of reinforced concrete core walls was obtained, and vulnerability performance of the structure can be analyzed and evaluated.