Abstract: In the dynamic design of high speed and high precision horizontal machining center, the contact parameters of guide surfaces had been acquired by the dynamic tests and they had been applied to the numerical simulation model to improve accuracy of the simulation model. The structural optimization based on ICM (independent continuous mapping) topology optimization theory, a new topology optimization method considering undesigning aggregates was put forward in the structural optimization design of machining center, was applied to design of the leading parts to improve both the static and dynamic properties of machining center. To the unavoidable resonance problems in the machine, using machine accessories a tuned damper was ably designed to control the vibration of machine.