According to the damage characteristics of skew bridges during earthquakes and the stiffness and strength of rubber bearings changing with low temperatures, the seismic behavior of a skew bridge isolated with lead rubber bearings (LRBs) was studied. 3-D nonlinear dynamic models of the bridge with various skew angles, which considering the pounding between girder and abutment by Hertz-damp impact model, were developed using the computational platform OpenSees. The distribution of pounding force at abutments with various skew angles was discussed. The seismic response of isolated bridge with two methods mechanical properties of the bearings were compared with each other. By investigating the relationships between seismic response of piers and skew angles, and various ambient temperature, it is shown that the seismic pounding is happened firstly at the obtuse corners of bridge deck due to the coupling of bidirectional translation and in-plane torsion motion of superstructure; and the in-plane rotation of skewed bridge deck is further increased by pounding response. The seismic response of isolated skew bridge is increased due to mechanical properties of LRBs changed by low temperature. If the effect of low temperatures is not considered, the shear and bending moment of piers was underestimated by about 10%,20% and 40% while the isolated bridge at low temperatures of 0℃、-10℃ and -30℃ than the case at nomal temperature.