In order to analyze the dynamic response mode of Kiewitt-6 single-layer reticulated shell with the substructure under impact, the shell with steel pipe column for numerical analysis was established by the ANSYS/ LS-DYNA program. Four dynamic response modes were put forward according the dynamic response. The influences of the impact energy, impact location, the stiffness of ring beams were studied. The impact test on single-layer reticulated shell model with steel pipe column was conducted. The dynamic stress, dynamic displacement and acceleration were measured and analyzed, and the damage patterns of impact columns were studied. The results show that the typical characteristics of response mode are the damage patterns of impact columns(slight damage, local dent， press-bend failure, shear failure).The dynamic response of reticulated shell with impact energy increases in addition to the response mode 4. The most unfavorable impact position is central column. The dynamic response of reticulated shell decreases with the increase of the stiffness of ring beams. And the numerical model is also proved to be reasonable by comparing the theoretical and experimental results．