医用水射流在不同力学性能皮肤上的注射效果研究

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振动与冲击 ›› 2024, Vol. 43 ›› Issue (13) : 153-161.

论文

李佳敏1，曾栋坪2，康勇1

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Injection effect of medical water jet on skins with different mechanical properties

LI Jiamin1, ZENG Dongping2, KANG Yong1

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摘要

为探究不同力学性能皮肤对无针注射效果的影响，通过注射不同质量分数的凝胶皮肤模型进行注射效果分析。首先，通过自制压力测试平台，分析不同注射参数下气动式无针注射系统微射流动力学特征；其次，采用气动式无针注射系统分别开展凝胶注射实验与离体猪肉组织注射实验，探究凝胶注射实验的可靠性；在此基础上，分别开展单层、双层及多层凝胶注射实验，探究多层结构组织及不同层间界面条件下气动式无针注射系统微射流的扩散特征。研究结果表明：随着凝胶杨氏模量增大，注射深度、扩散面积和注射完成率均减小；同时，分界面一定条件下起到促进药液横向扩散作用，疏松界面一定会出现层间积液，紧密界面可能出现层间漏液现象。研究结果可为无针注射系统在不同力学性能皮肤条件下的进一步发展应用提供理论依据和技术支撑。

Abstract

To explore the effect of needle-free injection on skin of different mechanical properties， gels of different mass fractions were injected. Firstly, the microjet dynamic characteristics of the air-powered needle-free injector were analyzed under different injection parameters with a self-made pressure test platform. Secondly, the air-powered needle-free injector was used to carry out gel injection experiments and porcine tissue injection experiments, so as to explore the reliability of gel injection experiments. On this basis, the single-layered, double-layered and multi-layered gel injection experiments were carried out to explore the dispersion characteristics of the microjet of the air-powered needle-free injector under the condition of multi-layered structure and different bound interfaces. The results demonstrate that with the increase of Young's modulus of gel， injection depth, dispersion area and injection completion rate decrease. Meanwhile, the interface plays a role in promoting the lateral dispersion. The injection liquid will necessarily appear in loose interfaces, while probably appear in tight interfaces. The results can provide theoretical basis and technical support for the further development and application of needle-free injection system on skin of different mechanical properties.

关键词

水射流技术 / 射流冲击特征 / 杨氏模量 / 皮肤厚度 / 射流扩散特征

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李佳敏1，曾栋坪2，康勇1. 医用水射流在不同力学性能皮肤上的注射效果研究[J]. 振动与冲击, 2024, 43(13): 153-161

LI Jiamin1, ZENG Dongping2, KANG Yong1. Injection effect of medical water jet on skins with different mechanical properties[J]. Journal of Vibration and Shock, 2024, 43(13): 153-161

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