In order to get the complete structural dynamic of the ball screw drive this paper proposes a hybrid modeling method. The ball screw is considered as a distributed-parameter model, while the other more rigid components are considered as lumped-parameter models. The axial, torsional and flexural vibrations of the screw are determined by the power balance and Ritz series method. The mass, stiffness and damping matrix of the system are obtained. Influences of parameters, such as table mass and table position, on the structural dynamic of the ball screw drive are discussed. The mode shapes for variable table position are obtained. The results reveal that the axial modes are sensitive to the table position and mass, while the torsional modes are insensitive to the table position and mass. Table position has a large influence on the flexural modes. Compared with the experimental results, the model can accurately capture the structural dynamic of the ball screw drive.