嗅球中神经元间的相互作用及同步运动分析

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振动与冲击 ›› 2013, Vol. 32 ›› Issue (2) : 175-181.

论文

嗅球中神经元间的相互作用及同步运动分析

徐爱蕾1，杜莹2，王如彬2

作者信息 +

Interaction between different cells in olfactory bulb and synchronous kinematic analysis

Xu Ailei1 , Du Yin2 , Wang Rubin2

Author information +

文章历史 +

摘要

嗅球对嗅觉信息的处理是嗅觉系统信号编码的一个重要环节，其中兴奋性的僧帽细胞（Mitral Cell, MC）与抑制性的颗粒细胞（Granular Cell, GC）的相互作用尤为关键。本文首先介绍了嗅觉系统网络中关于同步振荡的研究现状，然后建立嗅球中僧帽细胞及颗粒细胞的动力学模型，仿真得到了单个僧帽细胞、颗粒细胞以及僧帽细胞与颗粒细胞在耦合条件下神经元的发放模式。结果表明，僧帽细胞对颗粒细胞有兴奋性作用，而颗粒细胞对僧帽细胞有抑制性作用，细胞放电序列随着突触连接强度的改变而改变。此外，建立简单的嗅觉网络模型，分析了当颗粒细胞分别构成环形和网格状两种拓扑结构时，不同网络对两个僧帽细胞同步性的影响，用同步性指标ISI-distance刻画同步程度。数值分析表明颗粒细胞网格状的拓扑结构对僧帽细胞的同步性作用更为明显一些。

Abstract

Olfactory bulb plays an important part in signal encoding of olfactory system. The interaction between excitatory mitral cell and inhibitory granule cell is particularly crucial. In this paper, the current situation of synchronous oscillation in the network of olfactory system is firstly introduced. Then we set up the dynamical model of mitral cell and granular cell in the olfactory bulb. The simulation figures show the firing patterns of single mitral cell and single granular cell, as well as these two kinds of cells having a coupling relationship. The results indicate that Mitral cells have an excitatory effect on granular cells, and granular cells have an inhibitory effect on mitral cells. The firing pattern varies with different synaptic strength. In addition, we set up simple olfactory network models, discussing the influence of ring-like and grid-like neuronal network of granular cells on the synchronization of two mitral cells. Different types of firing synchronization are diagnosed by means of ISI-distance method. The numerical analysis indicates that grid-like neuronal network can make mitral cells synchronize better.

导出引用

徐爱蕾;杜莹;王如彬. 嗅球中神经元间的相互作用及同步运动分析[J]. 振动与冲击, 2013, 32(2): 175-181

Xu Ailei;Du Yin;Wang Rubin. Interaction between different cells in olfactory bulb and synchronous kinematic analysis [J]. Journal of Vibration and Shock, 2013, 32(2): 175-181