Considering the effects of the aerodynamics, vehicle dynamic responses of high-speed train in passing events are studied in this paper. For obtaining the aerodynamic load, a simplified geometry model of high-speed train (CRH-2) is built, and a 50-degree-of-freedom dynamic system is represented for modeling each of three cars which constitute the train, the three-dimensional compressible Reynolds-averaged Navier-Stokes equation, combined with the k-e two equations turbulence model, was solved by using finite volume method, and the motion of the train is carried out by using sliding meshes. The response of the train consider aerodynamic load or not are calculated by Multi-Body Simulation. The safety and riding quality of the train in passing events considering aerodynamics or not are discussed. It is found that, the aerodynamic force changes rapidly in the process of passing events, the aerodynamics has obvious effect on the vehicle system dynamics, which cause the train drastic vibration, the most serious deterioration of safety and riding quality can be found at the leading and tail car.