Quantification of evolutionary process of structural failure is one of the critical steps when carrying out performance-based seismic design for high-ride structures. In order to establish invalidation discrimination of diagrid tube structures, the calculation method of initial equivalent lateral stiffness of diagrid tube structures based on continuous method of structural deformation analysis was proposed firstly, and the deformed shape of the structural was also discussed. Then method of failure discrimination based on instantaneous equivalent ratio of stiffness to weight was proposed through entire stable equilibrium analysis. Eventually, rare earthquake elastoplastic time-history response analysis and quasi-static test have been performed for verifying the proposed method.