To investigate the vibration effect on setting wind-resistant bearing at isolation layer when the structure locates at large wind pressure area. Taking an actual base-isolated structure as background, goals were setted which structural horizontal damping coefficient is less than 0.53 and 0.40. setting or no-setting wind resistant bearing isolated models were established, though dynamic time-history analysis it is compared about structural seismic response. The results show that seismic response of the two isolation models is significantly decreased compared with seismic structure. For no setting wind resistant bearing model, LRB number is increased to meet the wind design requirements, but seismic effect is reduced. While for setting wind resistant bearing model, LRB number is reduced, which benefits seismic effect. Under normal operation and small earthquake, wind resistant bearing functions and isolation layer does not yield, when the structure suffers fortification earthquake , the wind resistant bearing shall yield and destroy and be out of work, which dose not affect the upper structure seismic effect.