Among the most factors causing the vibration of the high-speed pumps, one is the whirling motion of the impellers which rotate in an eccentric way with the interaction of the fluid force acting. In order to investigate its internal flow, a high-speed centrifugal pump was simulated based on the research scheme consist of three different flow rates, four different eccentricities and six different whirl frequency ratios by using the commercial software CFX. In addition, the effect of whirl frequency ratio, flow rate and eccentricity on internal flow of high-speed pump was also studied. The results show that: The low pressure area in inlet of impeller are minimum at the design point while eccentricity is close to zero; Under the condition of low flowrate, the number of vortex increased as the whirl frequency decreased when whirl frequency is negative; Under the condition of high flowrate, the number of vortex increased as the eccentricity increased when whirl frequency is negative; The tangential force Ft is weakly dependent on the eccentricities and whirl frequency ratios, while the component force direction on x-axis、y-axis、z-axis changes as the flow rate changes.